Gender differences in the risk factors for endothelial dysfunction in Chinese hypertensive patients: homocysteine is an independent risk factor in females.

ABSTRACT:

Objectives

Endothelial dysfunction plays a key role in the pathogenesis of cardiovascular disease. However, the gender-related differences in risk factors for endothelial dysfunction are controversial. We investigated the gender differences in the risk factor profiles for endothelial dysfunction in Chinese hypertensive patients.

Methods

Vascular endothelial functions in 213 hypertensive patients were measured by digital reactive hyperemia peripheral arterial tonometry (RH-PAT). Peripheral blood samples were collected, and the self-reported smoking and alcohol consumption status, age, body mass index, heart rate, blood pressure and drug administrations were recorded.

Results

RH-PAT indexes were attenuated in both male and female hypertensive patients [1.60 (1.38-2.02)

SUBMITTER: Cao C 

PROVIDER: S-EPMC4334966 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature