Ontology highlight
ABSTRACT:
SUBMITTER: Yang R
PROVIDER: S-EPMC4335710 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nature communications 20141216
Direct reprogramming provides a fundamentally new approach for the generation of patient-specific cells. Here, by screening a pool of candidate transcription factors, we identify that a combination of the three factors, MITF, SOX10 and PAX3, directly converts mouse and human fibroblasts to functional melanocytes. Induced melanocytes (iMels) activate melanocyte-specific networks, express components of pigment production and delivery system and produce melanosomes. Human iMels properly integrate i ...[more]