Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt.

ABSTRACT: Sleep is an essential biological process that is thought to have a critical role in metabolic regulation. In humans, reduced sleep duration has been associated with risk for metabolic disorders, including weight gain, diabetes, obesity, and cardiovascular disease. However, our understanding of the molecular mechanisms underlying effects of sleep loss is only in its nascent stages. In this study we used rat and human models to simulate modern-day conditions of restricted sleep and addressed cross-species consequences via comprehensive metabolite profiling. Serum from sleep-restricted rats was analyzed using polar and nonpolar methods in two independent datasets (n = 10 per study, 3,380 measured features, 407 identified). A total of 38 features were changed across independent experiments, wi

SUBMITTER: Weljie AM 

PROVIDER: S-EPMC4345602 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature