Dataset Information

CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival.

ABSTRACT:

Aims

We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC.

Methods

Gene expression and tissue microarray studies on a panel of RCC tissue were performed. Clinicopathological correlation was analysed using χ(2)/Fisher's exact test. Relapse-free survival, cancer-specific survival and overall survival were calculated for both CD1d high and low expressors. Survival outcomes were estimated with the Kaplan-Meier method and compared using Cox regression analysis.

Results

Gene expression microarray showed significant expression of CD1d in RCC versus normal renal tissue. By immunohistochemistry, we found that CD1d expression significantly associated with tumour stage/grade, higher relapse rates, poorer cancer-specific and overall survival.

Conclusions

CD1d expression on RCC correlated with aggressive disease and poorer clinical outcomes.

SUBMITTER: Chong TW

PROVIDER: S-EPMC4345982 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Publications

CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival.

Chong Tsung Wen TW Goh Fera Yiqian FY Sim Mei Yi MY Huang Hong Hong HH Thike Aye Aye AA Lim Weng Khong WK Teh Bin Tean BT Tan Puay Hoon PH

Journal of clinical pathology 20141204 3

<h4>Aims</h4>We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC.<h4>Methods</h4>Gene expression and tissue microarray studies on a panel of RCC tissue were performed. Clinicopathological correlation was analysed using χ(2)/Fisher's exact test. Relapse-free survival, cancer- ...[more]

PMID: 25477528

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Dataset Information

CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival.

Aims

Methods

Results

Conclusions

Publications

CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival.

Similar Datasets

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