Ontology highlight
ABSTRACT:
SUBMITTER: Yang CS
PROVIDER: S-EPMC4347017 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Nature communications 20150206
Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflammasome activation. NLRP3 inflammasome activation leads to an interaction between SHP and NLRP3, proteins that are both recruited to mitochondria. Overexpression of SHP competitively inhibits binding of NLRP3 to apoptosis-associated speck-lik ...[more]