Association between nicotine withdrawal and reward responsiveness in humans and rats.

ABSTRACT:

Importance

Reward-related disturbances after withdrawal from nicotine are hypothesized to contribute to relapse to tobacco smoking but mechanisms underlying and linking such processes remain largely unknown.

Objective

To determine whether withdrawal from nicotine affects reward responsiveness (ie, the propensity to modulate behavior as a function of prior reinforcement experience) across species using translational behavioral assessments in humans and rats.

Design, setting, participants

Experimental studies used analogous reward responsiveness tasks in both humans and rats to examine whether reward responsiveness varied in (1) an ad libitum smoking condition compared with a 24-hour acute nicotine abstinence condition in 31 human smokers with (n = 17) or without (n = 1

SUBMITTER: Pergadia ML 

PROVIDER: S-EPMC4353576 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature