The association of XRCC3 Thr241Met genetic variant with risk of prostate cancer: a meta-analysis.

ABSTRACT:

Background

Previous studies suggest that the X-ray repair cross-complementing group 3 gene (XRCC3) Thr241Met genetic variant could be potentially associated with the risk of prostate cancer. However, results from these published studies were conflicting rather than conclusive.

Objectives

his meta-analysis aimed to conduct a better understanding of the effects of XRCC3 Thr241Met genetic variant on prostate cancer risk.

Methods

We identified three eligible studies, 499 prostate cancer cases and 571 controls.

Results

Overall, significant associations were detected in the heterozygote comparison genetic model (CT versus (vs.) CC: OR = 0.71, 95% CI 0.53-0.94, Z =2.38, p= 0.017), and the dominant genetic model (TT/CT vs. CC: OR = 0.74, 95% CI 0.57-0.98, Z = 2.11, p =

SUBMITTER: Xuan G 

PROVIDER: S-EPMC4370129 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature