Ontology highlight
ABSTRACT:
SUBMITTER: Kleinridders A
PROVIDER: S-EPMC4371978 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Kleinridders Andre A Cai Weikang W Cappellucci Laura L Ghazarian Armen A Collins William R WR Vienberg Sara G SG Pothos Emmanuel N EN Kahn C Ronald CR
Proceedings of the National Academy of Sciences of the United States of America 20150302 11
Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a brain-specific knockout of the insulin receptor (NIRKO mice) exhibit brain mitochondrial dysfunction with reduced mitochondrial oxidative activity, increased levels of reactive oxygen species, and increased levels of lipid and protein oxidation in the striatum and nucleus accumbens. NIRKO mice also exhibit increased l ...[more]