Consequences of periodic α-to-β(3) residue replacement for immunological recognition of peptide epitopes.

ABSTRACT: Oligomers that contain both α- and β-amino acid residues, or "α/β-peptides", have emerged as promising mimics of signal-bearing polypeptides that can inhibit or augment natural protein-protein interactions. α/β-Peptides that contain a sufficient proportion of β residues evenly distributed along the sequence can be highly resistant to enzymatic degradation, which is favorable with regard to in vivo applications. Little is known, however, about recognition of α/β-peptides by the immune system. Prior studies have focused almost entirely on examples that contain a single β residue; such α/β-peptides frequently retain the immunological profile of the analogous α-peptide. We have conducted α-peptide vs α/β-peptide comparisons involving higher β residue content, focusing on molecules with αααβ an

SUBMITTER: Cheloha RW 

PROVIDER: S-EPMC4372116 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature