Ontology highlight
ABSTRACT:
SUBMITTER: Xie LX
PROVIDER: S-EPMC4373747 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Xie Letian X LX Williams Kevin J KJ He Cuiwen H CH Weng Emily E Khong San S Rose Tristan E TE Kwon Ohyun O Bensinger Steven J SJ Marbois Beth N BN Clarke Catherine F CF
Journal of lipid research 20150214 4
Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aromatic ring precursor in Q biosynthesis despite the recent finding that para-aminobenzoic acid (pABA) also serves as a ring precursor in Saccharomyces cerevisiae Q biosynthesis. In this study, we employed aromatic (13)C6-ring-labeled compounds includi ...[more]