Ontology highlight
ABSTRACT:
SUBMITTER: Moss CX
PROVIDER: S-EPMC4376731 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150327 3
The serine peptidases of Trypanosoma brucei have been viewed as potential drug targets. In particular, the S9 prolyl oligopeptidase subfamily is thought to be a good avenue for drug discovery. This is based on the finding that some S9 peptidases are secreted and active in the mammalian bloodstream, and that they are a class of enzyme against which drugs have successfully been developed. We collated a list of all serine peptidases in T. brucei, identifying 20 serine peptidase genes, of which nine ...[more]