MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance.

ABSTRACT:

Background

Despite present studies which suggested miR-133a as a promising biomarker for several cancers, there still exist no articles concerning the validated clinical significance of miR-133a in non-small cell lung cancer (NSCLC). Therefore, in this study, we targeted the correlation between miR-133a expression and clinicopathological significance in NSCLC patients.

Methods

The expression of miR-133a in 125 cases of NSCLC and their paired adjacent non-cancerous tissues was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Meanwhile, the relationship between miR-133a expression and several clinicopathological parameters and patient survival was analyzed.

Results

The relative level of miR-133a was 2.0108 ± 1.3334 in NSCLC tissues, s

SUBMITTER: Lan D 

PROVIDER: S-EPMC4409717 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature