Dataset Information

Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.

ABSTRACT:

Importance

Latino populations have one of the highest prevalences of type 2 diabetes worldwide.

Objectives

To investigate the association between rare protein-coding genetic variants and prevalence of type 2 diabetes in a large Latino population and to explore potential molecular and physiological mechanisms for the observed relationships.

Design, setting, and participants

Whole-exome sequencing was performed on DNA samples from 3756 Mexican and US Latino individuals (1794 with type 2 diabetes and 1962 without diabetes) recruited from 1993 to 2013. One variant was further tested for allele frequency and association with type 2 diabetes in large multiethnic data sets of 14,276 participants and characterized in experimental assays.