Suppression of the immunologic response to peanut during immunotherapy is often transient.

ABSTRACT:

Background

Studies suggest that oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) for food allergy hold promise; however, the immunologic mechanisms underlying these therapies are not well understood.

Objective

We sought to generate insights into the mechanisms and duration of suppression of immune responses to peanut during immunotherapy.

Methods

Blood was obtained from subjects at baseline and at multiple time points during a placebo-controlled trial of peanut OIT and SLIT. Immunologic outcomes included measurement of spontaneous and stimulated basophil activity by using automated fluorometry (histamine) and flow cytometry (activation markers and IL-4), measurement of allergen-induced cytokine expression in dendritic cell (DC)-T-cell cocultures by using m

SUBMITTER: Gorelik M 

PROVIDER: S-EPMC4426213 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature