Domain atrophy creates rare cases of functional partial protein domains.

ABSTRACT:

Background

Protein domains display a range of structural diversity, with numerous additions and deletions of secondary structural elements between related domains. We have observed a small number of cases of surprising large-scale deletions of core elements of structural domains. We propose a new concept called domain atrophy, where protein domains lose a significant number of core structural elements.

Results

Here, we implement a new pipeline to systematically identify new cases of domain atrophy across all known protein sequences. The output of this pipeline was carefully checked by hand, which filtered out partial domain instances that were unlikely to represent true domain atrophy due to misannotations or un-annotated sequence fragments. We identify 75 cases of domain at

SUBMITTER: Prakash A 

PROVIDER: S-EPMC4432964 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature