Ontology highlight
ABSTRACT:
SUBMITTER: Cheng P
PROVIDER: S-EPMC4437464 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Stem cell reports 20150423 5
Glioblastoma is a highly lethal cancer for which novel therapeutics are urgently needed. Two distinct subtypes of glioblastoma stem-like cells (GSCs) were recently identified: mesenchymal (MES) and proneural (PN). To identify mechanisms to target the more aggressive MES GSCs, we combined transcriptomic expression analysis and kinome-wide short hairpin RNA screening of MES and PN GSCs. In comparison to PN GSCs, we found significant upregulation and phosphorylation of the receptor tyrosine kinase ...[more]