Dataset Information

Seasonal variation in the month of birth in patients with skin cancer.

ABSTRACT:

Background

Month of birth influences the risk of developing several diseases. We investigated the influence of date of birth on melanoma skin cancer (MSC) and non-melanoma skin cancer (NMSC) incidence.

Methods

Enhanced cancer registry data were analysed including 1751 MSC and 15 200 NMSC.

Results

People born in February to April showed significantly elevated risks of NMSC compared with those born in summertime.

Conclusions

We demonstrated seasonality by date of birth for skin cancer incidence. Neonatal UV exposure may explain this finding.

SUBMITTER: La Rosa F

PROVIDER: S-EPMC4453742 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Publications

Seasonal variation in the month of birth in patients with skin cancer.

La Rosa F F Liso A A Bianconi F F Duca E E Stracci F F

British journal of cancer 20141007 9

<h4>Background</h4>Month of birth influences the risk of developing several diseases. We investigated the influence of date of birth on melanoma skin cancer (MSC) and non-melanoma skin cancer (NMSC) incidence.<h4>Methods</h4>Enhanced cancer registry data were analysed including 1751 MSC and 15 200 NMSC.<h4>Results</h4>People born in February to April showed significantly elevated risks of NMSC compared with those born in summertime.<h4>Conclusions</h4>We demonstrated seasonality by date of birth ...[more]

PMID: 25290092

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Project description:As apex predators, cetaceans are recognized as sentinels for the health of marine ecosystems. The ability to identify the impacts of anthropogenic contamination on the health of a species requires long term monitoring to establish baseline health parameters. This makes health measurements that can be sampled from free ranging animals highly desirable. In the current study, we investigate the utility of skin gene expression profiling to monitor the physiological, health, and contaminant exposure status in bottlenose dolphins. Remote integument biopsies were obtained from bottlenose dolphins at three locations in the northern Gulf of Mexico prior to oil exposure (May 2010) and during summer and winter of the two years (2010-2011) following their exposure to oil from the Deepwater Horizon oil spill. A bottlenose dolphin-specific oligonucleotide microarray was used to characterize the skin transcriptomes of 94 individuals from three genetically distinguishable populations in Barataria Bay, Louisiana, Chandeleur Sound, Louisiana, and Mississippi Sound, Mississippi. Location did not significantly affect the transcriptome patterns of the dolphins included in the study. In contrast, season had a profound effect on gene expression, with nearly one-third of all genes on the array differing significantly in expression between winter and the warmer seasons (p<0.01, fold-change >1.5). Gene ontology enrichment analysis revealed that processes related to cell proliferation, motility and differentiation dominated the seasonal differences in expression, which likely reflects the differences in ambient temperature to which the skin is exposed, and possibly changes in blood flow. More subtle differences were seen between spring and summer transcriptomes (1.5% differentially expressed), with two presumed oil-exposed animals presenting gene expression profiles more similar to the summer (exposed) animals than the other spring animals. Xenobiotic pathway components also showed some seasonal trends, which may reflect crosstalk between xenobiotic pathways and those regulating corticoids, hormones, and cytokines. Seasonal effects have not previously been considered in studies assessing gene expression in cetaceans, but clearly must be taken into account when applying transcriptomic analyses to investigate their exposure or health status.

Dataset Information

Seasonal variation in the month of birth in patients with skin cancer.

Background

Methods

Results

Conclusions

Publications

Seasonal variation in the month of birth in patients with skin cancer.

Similar Datasets

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