Ontology highlight
ABSTRACT:
SUBMITTER: Alonzo DA
PROVIDER: S-EPMC4455996 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Alonzo Diego A DA Magarvey Nathan A NA Schmeing T Martin TM
PloS one 20150604 6
Cereulide synthetase is a two-protein nonribosomal peptide synthetase system that produces a potent emetic toxin in virulent strains of Bacillus cereus. The toxin cereulide is a depsipeptide, as it consists of alternating aminoacyl and hydroxyacyl residues. The hydroxyacyl residues are derived from keto acid substrates, which cereulide synthetase selects and stereospecifically reduces with imbedded ketoreductase domains before incorporating them into the growing depsipeptide chain. We present an ...[more]