Memory acquisition and retrieval impact different epigenetic processes that regulate gene expression.

ABSTRACT:

Background

A fundamental question in neuroscience is how memories are stored and retrieved in the brain. Long-term memory formation requires transcription, translation and epigenetic processes that control gene expression. Thus, characterizing genome-wide the transcriptional changes that occur after memory acquisition and retrieval is of broad interest and importance. Genome-wide technologies are commonly used to interrogate transcriptional changes in discovery-based approaches. Their ability to increase scientific insight beyond traditional candidate gene approaches, however, is usually hindered by batch effects and other sources of unwanted variation, which are particularly hard to control in the study of brain and behavior.

Results

We examined genome-wide gene expression

SUBMITTER: Peixoto LL 

PROVIDER: S-EPMC4460846 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature