Ontology highlight
ABSTRACT:
SUBMITTER: Cole A
PROVIDER: S-EPMC4461837 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Cancer cell 20150601 6
From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial protease that has structural similarity to the cytoplasmic proteosome is increased in leukemic cells from approximately half of all patients with AML. Genetic or chemical inhibition of ClpP killed cells from both human AML cell lines and primary samples in which the cells showed elevated ClpP expression but did not affec ...[more]