Dataset Information
Gammadelta (γδ) T lymphocytes do not impact the development of early atherosclerosis.
Ontology highlight
ABSTRACT: Objective
Gammadelta (γδ) T cells are a subset of pro-inflammatory innate-like T lymphocytes that serve as a bridge between innate and adaptive immunity. γδ T cells are highly enriched in cholesterol compared to αβ T cells. In this study, we aimed to identify the role of γδ T cells in atherosclerosis, a cholesterol and inflammation-driven disease.Methods
We found that the percentages of γδ T cells are increased in ApoE(-/-) mice fed a Western diet. We generated TCRδ(-/-)ApoE(-/-) mice and fed them either rodent chow or a Western diet for ten weeks for the assessment of atherosclerosis.Results
The atherosclerotic lesion size in diet-fed TCRδ(-/-)ApoE(-/-) mice was similar to that of diet-fed ApoE(-/-) mice. There were no differences in cytokine production or numbers of αβ T cells in aorta of TCRδ(-/-)ApoE(-/-) mice. Plasma lipoprotein profiles were unchanged by the absence of γδ T cells.Conclusion
Our data suggest that γδ T cells do not contribute to early atherosclerotic plaque development.
SUBMITTER: Cheng HY
PROVIDER: S-EPMC4469487 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Gammadelta (γδ) T lymphocytes do not impact the development of early atherosclerosis.
Atherosclerosis 20140320 2
<h4>Objective</h4>Gammadelta (γδ) T cells are a subset of pro-inflammatory innate-like T lymphocytes that serve as a bridge between innate and adaptive immunity. γδ T cells are highly enriched in cholesterol compared to αβ T cells. In this study, we aimed to identify the role of γδ T cells in atherosclerosis, a cholesterol and inflammation-driven disease.<h4>Methods</h4>We found that the percentages of γδ T cells are increased in ApoE(-/-) mice fed a Western diet. We generated TCRδ(-/-)ApoE(-/-) ...[more]
