Identifying Novel Clinical Surrogates to Assess Human Bone Fracture Toughness.

ABSTRACT: Fracture risk does not solely depend on strength but also on fracture toughness; ie, the ability of bone material to resist crack initiation and propagation. Because resistance to crack growth largely depends on bone properties at the tissue level, including collagen characteristics, current X-ray based assessment tools may not be suitable to identify age-related, disease-related, or treatment-related changes in fracture toughness. To identify useful clinical surrogates that could improve the assessment of fracture resistance, we investigated the potential of (1)H nuclear magnetic resonance spectroscopy (NMR) and reference point indentation (RPI) to explain age-related variance in fracture toughness. Harvested from cadaveric femurs (62 human donors), single-edge notched beam (SENB) specime

SUBMITTER: Granke M 

PROVIDER: S-EPMC4478129 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature