Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.

ABSTRACT:

Unlabelled

Bipolar disorder (BD) is a psychiatric disease considered to polygenic with multiple factors in genetics, each of which is not dominant but collaborative during pathogenic progression. We describe a method that estimates the collaborative contribution to the disease between a certain well-studied pathway and the other candidate pathway using Gene Set Enrichment Analysis (GSEA). We describe a modified GSEA (improved derivation) to identify genes that are significantly and differentially expressed between disease and non-disease states and that are consistently co-expressed with a target pathway which is deeply related to disease etiology. The modified GSEA uses available gene expression data to identify molecular mechanism (ubiquitin-proteasome and inflammatory response)

SUBMITTER: Sawai H 

PROVIDER: S-EPMC4479050 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature