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Nephrotic-range Albuminuria as the presenting symptom of Dent-2 disease.

ABSTRACT:

Unlabelled

Dent disease is a rare X-linked tubulopathy with low molecular weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis and progressive renal failure. We describe the case of a 9-year-old boy who presented with nephrotic-range albuminuria at the age of 3 years. In the absence of a clear diagnosis, a renal biopsy was performed at 4 years, which revealed minimal change disease. Due to the presence of low molecular weight proteinuria, even in the absence of hypercalciuria, a diagnosis of Dent disease was considered. While there were no mutations in the CLCN5 gene, the diagnosis was confirmed by the presence of a missense mutation (p.Arg318Cys) in the OCRL gene.

Conclusion

Given the large phenotypic variability of the disease and based on our experience, we believe that children with low molecular weight proteinuria, even without hypercalciuria, should be investigated for Dent disease.

SUBMITTER: De Mutiis C

PROVIDER: S-EPMC4479313 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Nephrotic-range Albuminuria as the presenting symptom of Dent-2 disease.

De Mutiis Chiara C Pasini Andrea A La Scola Claudio C Pugliese Fabrizio F Montini Giovanni G

Italian journal of pediatrics 20150625

<h4>Unlabelled</h4>Dent disease is a rare X-linked tubulopathy with low molecular weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis and progressive renal failure. We describe the case of a 9-year-old boy who presented with nephrotic-range albuminuria at the age of 3 years. In the absence of a clear diagnosis, a renal biopsy was performed at 4 years, which revealed minimal change disease. Due to the presence of low molecular weight proteinuria, even in the absence of hypercalc ...[more]

PMID: 26108450

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