Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.

ABSTRACT: Tumor suppressor PTEN mainly functions at two subcellular locations, the plasma membrane and the nucleus. At the plasma membrane, PTEN dephosphorylates the tumorigenic second messenger PIP3, which drives cell proliferation and migration. In the nucleus, PTEN controls DNA repair and genome stability independently of PIP3. Whereas the concept that a conformational change regulates protein function through post-translational modifications has been well established in biology, it is unknown whether a conformational change simultaneously controls dual subcellular localizations of proteins. Here, we discovered that opening the conformation of PTEN is the crucial upstream event that determines its key dual localizations of this crucial tumor suppressor. We identify a critical conformational switc

SUBMITTER: Nguyen HN 

PROVIDER: S-EPMC4517176 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature