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Single-cell magnetic imaging using a quantum diamond microscope.

ABSTRACT: We apply a quantum diamond microscope for detection and imaging of immunomagnetically labeled cells. This instrument uses nitrogen-vacancy (NV) centers in diamond for correlated magnetic and fluorescence imaging. Our device provides single-cell resolution and a field of view (∼1 mm(2)) two orders of magnitude larger than that of previous NV imaging technologies, enabling practical applications. To illustrate, we quantified cancer biomarkers expressed by rare tumor cells in a large population of healthy cells.

SUBMITTER: Glenn DR

PROVIDER: S-EPMC4521973 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Single-cell magnetic imaging using a quantum diamond microscope.

Glenn D R DR Lee K K Park H H Weissleder R R Yacoby A A Lukin M D MD Lee H H Walsworth R L RL Connolly C B CB

Nature methods 20150622 8

We apply a quantum diamond microscope for detection and imaging of immunomagnetically labeled cells. This instrument uses nitrogen-vacancy (NV) centers in diamond for correlated magnetic and fluorescence imaging. Our device provides single-cell resolution and a field of view (∼1 mm(2)) two orders of magnitude larger than that of previous NV imaging technologies, enabling practical applications. To illustrate, we quantified cancer biomarkers expressed by rare tumor cells in a large population of ...[more]

PMID: 26098019

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