Dataset Information
Polymorphisms and phenotypic analysis of cytochrome P450 3A4 in the Uygur population in northwest China.
Ontology highlight
ABSTRACT: Purpose
Genetic polymorphisms in CYP3A4 can change its activity to a certain degree, thus leading to differences among different populations in drug efficacy or adverse drug reactions.Methods
The study was intended to validate the genetic polymorphisms in CYP3A4 in Uygur Chinese population, we sequenced and screened for genetic variants including 5'UTR, promoters, exons, introns, and 3'UTR region of the whole CYP3A4 gene in 100 unrelated, healthy.Results
Twenty-one genetic polymorphisms in CYP3A4, and nine of them were novel. We detected CYP3A4*8, a putative poor-metabolizer allele, with the frequency of 0.5% in Uygur population. Tfsitescan revealed that the density of transcription factor varied in the different promoter regions, among which some were key regions for transcription factor binding.Conclusion
our results provide basic information about CPY3A4 alleles in Uygur and suggest that the enzymatic activities of CPY3A4 may differ among the diverse ethnic populations of China.
SUBMITTER: Jin T
PROVIDER: S-EPMC4525935 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Polymorphisms and phenotypic analysis of cytochrome P450 3A4 in the Uygur population in northwest China.
International journal of clinical and experimental pathology 20150601 6
<h4>Purpose</h4>Genetic polymorphisms in CYP3A4 can change its activity to a certain degree, thus leading to differences among different populations in drug efficacy or adverse drug reactions.<h4>Methods</h4>The study was intended to validate the genetic polymorphisms in CYP3A4 in Uygur Chinese population, we sequenced and screened for genetic variants including 5'UTR, promoters, exons, introns, and 3'UTR region of the whole CYP3A4 gene in 100 unrelated, healthy.<h4>Results</h4>Twenty-one geneti ...[more]