Clinically Relevant Molecular Subtypes in Leiomyosarcoma.

ABSTRACT:

Purpose

Leiomyosarcoma is a malignant neoplasm with smooth muscle differentiation. Little is known about its molecular heterogeneity and no targeted therapy currently exists for leiomyosarcoma. Recognition of different molecular subtypes is necessary to evaluate novel therapeutic options. In a previous study on 51 leiomyosarcomas, we identified three molecular subtypes in leiomyosarcoma. The current study was performed to determine whether the existence of these subtypes could be confirmed in independent cohorts.

Experimental design

Ninety-nine cases of leiomyosarcoma were expression profiled with 3'end RNA-Sequencing (3SEQ). Consensus clustering was conducted to determine the optimal number of subtypes.

Results

We identified 3 leiomyosarcoma molecular subtypes and co

SUBMITTER: Guo X 

PROVIDER: S-EPMC4526352 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature