Molecular classification of Crohn's disease reveals two clinically relevant subtypes.

ABSTRACT:

Objective

The clinical presentation and course of Crohn's disease (CD) is highly variable. We sought to better understand the cellular and molecular mechanisms that guide this heterogeneity, and characterise the cellular processes associated with disease phenotypes.

Design

We examined both gene expression and gene regulation (chromatin accessibility) in non-inflamed colon tissue from a cohort of adult patients with CD and control patients. To support the generality of our findings, we analysed previously published expression data from a large cohort of treatment-naïve paediatric CD and control ileum.

Results

We found that adult patients with CD clearly segregated into two classes based on colon tissue gene expression-one that largely resembled the normal colon and one

SUBMITTER: Weiser M 

PROVIDER: S-EPMC5426990 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature