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Erythropoietin dampens injury-induced microglial motility.

ABSTRACT: Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular motility.

SUBMITTER: Mitkovski M

PROVIDER: S-EPMC4527993 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Erythropoietin dampens injury-induced microglial motility.

Mitkovski Miso M Dahm Liane L Heinrich Ralf R Monnheimer Mathieu M Gerhart Simone S Stegmüller Judith J Hanisch Uwe-Karsten UK Nave Klaus-Armin KA Ehrenreich Hannelore H

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150513 8

Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular mo ...[more]

PMID: 25966953

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