Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis.

ABSTRACT:

Introduction

Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability.

Methods

36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3 T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2(*) relaxometry and magnetisation transfer imaging for lesion tissue characterization. Lesions were classified according to the extent of inflammation/neurodegeneration. A generalized linea

SUBMITTER: Bonnier G 

PROVIDER: S-EPMC4532805 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature