Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature.

ABSTRACT:

Background

Current studies of environmental health suggest a link between air pollution components, such as particulate matter (PM), and various diseases. However, the specific genes and regulatory mechanisms implicated in PM-induced diseases remain largely unknown. Epigenetic systems such as covalent modification of histones in chromatin may mediate environmental factors in gene regulation. Investigating the relationships between PM exposure and histone modification status may help understand the mechanisms underlying environment-associated health conditions.

Methods

In this study, we obtained genome-wide profiles of H3K27ac (histone 3 lysine 27 acetylation), known to be an active gene regulatory histone modification marker, in blood samples collected from four Chinese indi

SUBMITTER: Liu C 

PROVIDER: S-EPMC4537530 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature