Ontology highlight
ABSTRACT:
SUBMITTER: Guo X
PROVIDER: S-EPMC4538705 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Nature communications 20150814
Retinitis pigmentosa is a leading cause of inherited blindness, with no effective treatment currently available. Mutations primarily in genes expressed in rod photoreceptors lead to early rod death, followed by a slower phase of cone photoreceptor death. Rd1 mice provide an invaluable animal model to evaluate therapies for the disease. We previously reported that overexpression of histone deacetylase 4 (HDAC4) prolongs rod survival in rd1 mice. Here we report a key role of a short N-terminal dom ...[more]