Effects of sleep and wake on astrocytes: clues from molecular and ultrastructural studies.

ABSTRACT:

Background

Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral state. Yet, little is known about the effects of sleep and wake on astrocytes.

Results

Here we show that sleep and wake strongly affect both astrocytic gene expression and ultrastructure in the mouse brain. Using translating ribosome affinity purification technology and microarrays, we find that 1.4 % of all astrocytic transcripts in the forebrain are dependent on state (three groups, sleep, wake, short sleep deprivation; six mice per group). Sleep upregulates a few sel

SUBMITTER: Bellesi M 

PROVIDER: S-EPMC4548305 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature