Exploring threats to generalisability in a large international rehabilitation trial (AVERT).

ABSTRACT:

Objective

The purpose of this paper is to examine potential threats to generalisability of the results of a multicentre randomised controlled trial using data from A Very Early Rehabilitation Trial (AVERT).

Design

AVERT is a prospective, parallel group, assessor-blinded randomised clinical trial. This paper presents data assessing the generalisability of AVERT.

Setting

Acute stroke units at 44 hospitals in 8 countries.

Participants

The first 20,000 patients screened for AVERT, of whom 1158 were recruited and randomised.

Model

We use the Proximal Similarity Model, which considers the person, place, and setting and practice, as a framework for considering generalisability. As well as comparing the recruited patients with the target population, we also perf

SUBMITTER: Bernhardt J 

PROVIDER: S-EPMC4550737 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature