Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics.

ABSTRACT:

Objective

Triglyceride-rich lipoproteins have emerged as causal risk factors for developing coronary heart disease independent of low-density lipoprotein cholesterol levels. Apolipoprotein C-III (ApoC-III) modulates triglyceride-rich lipoprotein metabolism through inhibition of lipoprotein lipase and hepatic uptake of triglyceride-rich lipoproteins. Mutations causing loss-of-function of ApoC-III lower triglycerides and reduce coronary heart disease risk, suggestive of a causal role for ApoC-III. Little data exist about the relationship of ApoC-III, triglycerides, and atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Here, we examined the relationships between plasma ApoC-III, triglycerides, and coronary artery calcification in patients with T2DM.

Approach and res

SUBMITTER: Qamar A 

PROVIDER: S-EPMC4556282 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature