Browse
Submit Data
Databases
API
Help

Dataset Information

53 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Synthesis and Magneto-Thermal Actuation of Iron Oxide Core-PNIPAM Shell Nanoparticles.

ABSTRACT: Superparamagnetic nanoparticles have been proposed for many applications in biotechnology and medicine. In this paper, it is demonstrated how the excellent colloidal stability and magnetic properties of monodisperse and individually densely grafted iron oxide nanoparticles can be used to manipulate reversibly the solubility of nanoparticles with a poly(N-isopropylacrylamide)nitrodopamine shell. "Grafting-to" and "grafting-from" methods for synthesis of an irreversibly anchored brush shell to monodisperse, oleic acid coated iron oxide cores are compared. Thereafter, it is shown that local heating by magnetic fields as well as global thermal heating can be used to efficiently and reversibly aggregate, magnetically extract nanoparticles from solution and spontaneously redisperse them. The coupling of magnetic and thermally responsive properties points to novel uses as smart materials, for example, in integrated devices for molecular separation and extraction.

SUBMITTER: Kurzhals S

PROVIDER: S-EPMC4559841 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Synthesis and Magneto-Thermal Actuation of Iron Oxide Core-PNIPAM Shell Nanoparticles.

Kurzhals Steffen S Zirbs Ronald R Reimhult Erik E

ACS applied materials & interfaces 20150821 34

Superparamagnetic nanoparticles have been proposed for many applications in biotechnology and medicine. In this paper, it is demonstrated how the excellent colloidal stability and magnetic properties of monodisperse and individually densely grafted iron oxide nanoparticles can be used to manipulate reversibly the solubility of nanoparticles with a poly(N-isopropylacrylamide)nitrodopamine shell. "Grafting-to" and "grafting-from" methods for synthesis of an irreversibly anchored brush shell to mon ...[more]

PMID: 26270412

Similar Datasets

Automated droplet reactor for the synthesis of iron oxide/gold core-shell nanoparticles.

Project description:Core-shell nanoparticles are promising candidates for theranostic drugs, as they combine different intrinsic properties with a small size and large surface area. However, their controlled synthesis, or the screening and optimization of synthesis conditions are often difficult and labor intensive. Through the precise control over mass and heat transfer, and automatization possibilities, microfluidic devices could be a solution to this problem in a lab scale synthesis. Here, we demonstrate a microfluidic, capillary, droplet reactor for the multi-step synthesis of iron oxide/gold core-shell nanoparticles. Through the integration of a transmission measurement at the outlet of the reactor, synthesis results can be monitored in a real-time manner. This allowed for the implementation of an optimization algorithm. Starting from three separate initial guesses, the algorithm converged to the same synthesis conditions in less than 30 minutes for each initial guess. These conditions resulted in diameter for the iron oxide core of 5.8 ± 1.4 nm, a thickness for the gold shell of 3.5 ± 0.6 nm, and a total diameter of the core-shell particles of 13.1 ± 2.5 nm. Finally, applications of the iron oxide/gold core-shell nanoparticles were demonstrated for Surface Enhanced Raman Spectroscopy (SERS), photothermal therapy, and magnetic resonance imaging (MRI).

| S-EPMC6997455 | biostudies-literature

Effect of dopamine covered iron oxide core - titanium dioxide shell nanoparticles on HeLa cells

Project description:Gene expression analysis of HeLa cell samples treated with nanoparticles for 2 or 4 hours, with matching non-treated samples as controls - exact cell culture growing conditions were replicated, same cell numbers plated in matching pairs of flasks Dopamine covered Fe3O4@TiO2 nanoparticles were added to cells grown for 16h and incubated fror 2 or 4 hours

2016-10-15 | GSE88786 | GEO

Remote Actuation of Apoptosis in Liver Cancer Cells via Magneto-Mechanical Modulation of Iron Oxide Nanoparticles.

Project description:Lysosome-activated apoptosis represents an alternative method of overcoming tumor resistance compared to traditional forms of treatment. Pulsed magnetic fields open a new avenue for controlled and targeted initiation of lysosomal permeabilization in cancer cells via mechanical actuation of magnetic nanomaterials. In this study we used a noninvasive tool; namely, a benchtop pulsed magnetic system, which enabled remote activation of apoptosis in liver cancer cells. The magnetic system we designed represents a platform that can be used in a wide range of biomedical applications. We show that liver cancer cells can be loaded with superparamagnetic iron oxide nanoparticles (SPIONs). SPIONs retained in lysosomal compartments can be effectively actuated with a high intensity (up to 8 T), short pulse width (~15 µs), pulsed magnetic field (PMF), resulting in lysosomal membrane permeabilization (LMP) in cancer cells. We revealed that SPION-loaded lysosomes undergo LMP by assessing an increase in the cytosolic activity of the lysosomal cathepsin B. The extent of cell death induced by LMP correlated with the accumulation of reactive oxygen species in cells. LMP was achieved for estimated forces of 700 pN and higher. Furthermore, we validated our approach on a three-dimensional cellular culture model to be able to mimic in vivo conditions. Overall, our results show that PMF treatment of SPION-loaded lysosomes can be utilized as a noninvasive tool to remotely induce apoptosis.

| S-EPMC6966689 | biostudies-literature

Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia.

Project description:Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.

| S-EPMC4427608 | biostudies-literature

Synthesis of bi-phase dispersible core-shell FeAu@ZnO magneto-opto-fluorescent nanoparticles.

Project description:Bi-phase dispersible core-shell FeAu@ZnO magneto-opto-fluorescent nanoparticles were synthesized by a modified nanoemulsion process using poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEO-PPO-PEO) as the surfactant. The morphology and crystal structure of the nanoparticles were studied by TEM/HRTEM and XRD. The nanoparticles manifest soft ferromagnetic and/or near superparamagnetic behavior with a small coercivity of ~19 Oe at room temperature. The corresponding magnetic hysteresis curves were elucidated by the modified Langevin equation. The FTIR study confirms the PEO-PPO-PEO molecules on the surface of the nanoparticles. The UV-vis and PL results reveal the well-behaved absorption bands including surface plasmon resonance and multiple visible fingerprint photoluminescent emissions of the nanoparticles dispersed in both hydrophilic and hydrophobic solvents. Moreover, the processes of solvent dispersion-collection of the nanoparticles were demonstrated for application readiness of such core-shell nanostructures.

| S-EPMC4637858 | biostudies-other

Iron Oxide-Silica Core-Shell Nanoparticles Functionalized with Essential Oils for Antimicrobial Therapies.

Project description:Recent years have witnessed a tremendous interest in the use of essential oils in biomedical applications due to their intrinsic antimicrobial, antioxidant, and anticancer properties. However, their low aqueous solubility and high volatility compromise their maximum potential, thus requiring the development of efficient supports for their delivery. Hence, this manuscript focuses on developing nanostructured systems based on Fe3O4@SiO2 core-shell nanoparticles and three different types of essential oils, i.e., thyme, rosemary, and basil, to overcome these limitations. Specifically, this work represents a comparative study between co-precipitation and microwave-assisted hydrothermal methods for the synthesis of Fe3O4@SiO2 core-shell nanoparticles. All magnetic samples were characterized by X-ray diffraction (XRD), gas chromatography-mass spectrometry (GC-MS), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), zeta potential, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetry and differential scanning calorimetry (TG-DSC), and vibrating sample magnetometry (VSM) to study the impact of the synthesis method on the nanoparticle formation and properties, in terms of crystallinity, purity, size, morphology, stability, and magnetization. Moreover, the antimicrobial properties of the synthesized nanocomposites were assessed through in vitro tests on Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. In this manner, this study demonstrated the efficiency of the core-shell nanostructured systems as potential applications in antimicrobial therapies.

| S-EPMC8467872 | biostudies-literature

Iron oxide-carbon core-shell nanoparticles for dual-modal imaging-guided photothermal therapy.

Project description:Nanostructured materials that have low tissue toxicity, multi-modal imaging capability and high photothermal conversion efficiency have great potential to enable image-guided near infrared (NIR) photothermal therapy (PTT). Here, we report a bifunctional nanoparticle (BFNP, ∼16 nm) comprised of a magnetic Fe3O4 core (∼9.1 nm) covered by a fluorescent carbon shell (∼3.4 nm) and prepared via a one-pot solvothermal synthesis method using ferrocene as the sole source. The BFNP exhibits excitation wavelength-tunable, upconverted and near-infrared (NIR) fluorescence property due to the presence of the carbon shell, and superparamagnetic behavior resulted from the Fe3O4 core. BFNPs demonstrate dual-modal imaging capacity both in vitro and in vivo with fluorescent imaging excited under a varying wavelength from 405 nm to 820 nm and with T2-weighted magnetic resonance imaging (r2 = 264.76 mM-1 s-1). More significantly, BFNPs absorb and convert NIR light to heat enabling photothermal therapy as demonstrated mice bearing C6 glioblastoma. These BFNPs show promise as an advanced nanoplatform to provide imaging guided photothermal therapy.

| S-EPMC6365181 | biostudies-literature

Magneto-fluorescent core-shell supernanoparticles.

Project description:Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close-packed magnetic nanoparticle 'core', which is fully surrounded by a 'shell' of fluorescent quantum dots. A thin layer of silica coating provides high colloidal stability and biocompatibility, and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.

| S-EPMC4264679 | biostudies-literature

Micron-Sized Silica-PNIPAM Core-Shell Microgels with Tunable Shell-To-Core Ratio.

Project description:Micron-sized hard core-soft shell hybrid microgels are promising model systems for studies of soft matter as they enable in-situ optical investigations and their structures/morphologies can be engineered with a great variety. Yet, protocols that yield micron-sized core-shell microgels with a tailorable shell-to-core size ratio are rarely available. In this work, we report on the one-pot synthesis protocol for micron-sized silica-poly(N-isopropylacrylamide) core-shell microgels that has excellent control over the shell-to-core ratio. Small-angle light scattering and microscopy of 2- and 3-dimensional assemblies of the synthesized microgels confirm that the produced microgels are monodisperse and suitable for optical investigation even at high packing fractions.

| S-EPMC9407347 | biostudies-literature

Synthesis of trimetallic iron-boron core and gold shell nanoparticles for experimental cancer radiotherapy.

Project description:Cancer is a significant and constantly growing clinical problem all over the word. For many types of cancer there has been little change in mortality rate of CRC in the past decades and treatment options are limited. A striking example is malignant Glioblastoma (GBM) which exhibits a high degree of infiltration of surrounding healthy brain tissue, extremely high mortality rate, morbidity and most life-years lost of any cancer. Considerable research efforts in the last several decades have failed to improve these outcomes. Boron Capture Neutron Therapy (BNCT) is an experimental radiotherapy (RT) that shows the best hope for the patients for whom all current therapies fail. BNCT involves the intracellular release of alpha and Li-ion particles from boron in response to neutron beam and therefore its success is critically dependent on achieving high intracellular concentrations of boron atoms within the cancerous cells. Boron phenylalanine (BPA) is the most used compound to deliver boron atoms, but achieving high intracellular concentration of BPA is difficult with this small molecule compound and is an absolute limiting factor for the better outcome of BNCT. Our approach focused on a delivery of a high and stable concentration of boron atoms in a form of novel trimetallic core-shell nanoparticles, combining boron for BNCT and iron for magnetic targeting in the core, and a gold shell for stability and attachment of targeting therapeutic peptides. The research was targeted towards comparing different synthesis variables to form these core-shell particles and incorporate as much boron into the core as possible via redox-transmetalation. Partial gold shells were formed around the core via island growth with a molar ratio of Fe/B of 0.64 and high incorporation of boron.

| S-EPMC11422082 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data