Dual-topology insertion of a dual-topology membrane protein.
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ABSTRACT:
SUBMITTER: Woodall NB
PROVIDER: S-EPMC4560821 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Dual-topology insertion of a dual-topology membrane protein.
Woodall Nicholas B NB Yin Ying Y Bowie James U JU
Nature communications 20150826
Some membrane transporters are dual-topology dimers in which the subunits have inverted transmembrane topology. How a cell manages to generate equal populations of two opposite topologies from the same polypeptide chain remains unclear. For the dual-topology transporter EmrE, the evidence to date remains consistent with two extreme models. A post-translational model posits that topology remains malleable after synthesis and becomes fixed once the dimer forms. A second, co-translational model, po ...[more]
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