The Interplay of Genetics, Behavior, and Pain with Depressive Symptoms in the Elderly.

ABSTRACT:

Purpose of study

About 25% of older adults suffer from depressive symptoms. Commonly studied candidate genes associated with depression include those that influence serotonin (SLC6A4), dopamine (COMT), or neuroplasticity (BDNF, NTRK3). However, the majority of candidate gene studies do not consider the interplay of genetics, demographic, clinical, and behavioral factors and how they jointly contribute to depressive symptoms among older adults. The purpose of this study was to gain a more comprehensive understanding of depressive symptoms among older adults.

Design and methods

In this descriptive study, demographic, behavioral, and clinical characteristics (age, gender, comorbidities, volunteering, physical activity, pain, and fear of falling) were obtained via interview of 1

SUBMITTER: Klinedinst NJ 

PROVIDER: S-EPMC4566914 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature