Effects of an opioid (proenkephalin) polymorphism on neural response to errors in health and cocaine use disorder.

ABSTRACT: Chronic exposure to drugs of abuse perturbs the endogenous opioid system, which plays a critical role in the development and maintenance of addictive disorders. Opioid genetics may therefore play an important modulatory role in the expression of substance use disorders, but these genes have not been extensively characterized, especially in humans. In the current imaging genetics study, we investigated a single nucleotide polymorphism (SNP) of the protein-coding proenkephalin gene (PENK: rs2609997, recently shown to be associated with cannabis dependence) in 55 individuals with cocaine use disorder and 37 healthy controls. Analyses tested for PENK associations with fMRI response to error (during a classical color-word Stroop task) and gray matter volume (voxel-based morphometry) as a functi

SUBMITTER: Moeller SJ 

PROVIDER: S-EPMC4567394 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature