Ontology highlight
ABSTRACT:
SUBMITTER: Mehta A
PROVIDER: S-EPMC4577845 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Mehta Arnav A Mann Mati M Zhao Jimmy L JL Marinov Georgi K GK Majumdar Devdoot D Garcia-Flores Yvette Y Du Xiaomi X Erikci Erdem E Chowdhury Kamal K Baltimore David D
The Journal of experimental medicine 20150914 10
MicroRNAs have emerged as key regulators of B cell fate decisions and immune function. Deregulation of several microRNAs in B cells leads to the development of autoimmune disease and cancer in mice. We demonstrate that the microRNA-212/132 cluster (miR-212/132) is induced in B cells in response to B cell receptor signaling. Enforced expression of miR-132 results in a block in early B cell development at the prepro-B cell to pro-B cell transition and induces apoptosis in primary bone marrow B cel ...[more]