Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins.
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ABSTRACT:
SUBMITTER: Qian J
PROVIDER: S-EPMC4581848 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins.
Qian Jin J Le Duff Yann Y Wang Yimeng Y Pan Qinghua Q Ding Shilei S Zheng Yi-Min YM Liu Shan-Lu SL Liang Chen C
Virology 20141107
Interferon-induced transmembrane (IFITM) proteins inhibit the entry of a large number of viruses. Not surprisingly, many viruses are refractory to this inhibition. In this study, we report that different strains of HIV and SIV are inhibited by human IFITM proteins to various degrees, with SIV of African green monkeys (SIV(AGM)) being mostly restricted by human IFITM2. Interestingly, SIV(AGM) is as much inhibited by human IFITM2 as by IFITM3 of its own host African green monkeys. Our data further ...[more]
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