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Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.
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ABSTRACT: Background
Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation.Findings
We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins.Conclusions
This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers.
SUBMITTER: Sliepen K
PROVIDER: S-EPMC4583754 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.
Retrovirology 20150926
<h4>Background</h4>Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation.<h4>Findings</h4>We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher ne ...[more]