Heritability of young- and old-onset ischaemic stroke.

ABSTRACT:

Background and purpose

Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples.

Methods

This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated

SUBMITTER: Bluher A 

PROVIDER: S-EPMC4600023 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature