Quercetin conjugated poly(β-amino esters) nanogels for the treatment of cellular oxidative stress.

ABSTRACT: PβAE polymers have emerged as highly promising candidates for biomedical and drug delivery applications owing to their tunable, degradable and pH sensitive properties. These polymeric systems can serve as prodrug carriers for the delivery of bioactive compounds which suffer from poor aqueous solubility, low bioavailability and are biologically unstable, such as the antioxidant, quercetin. Using acrylate functionalized quercetin, it is possible to incorporate the polyphenol into the backbone of the polymer matrix, permitting slow release of the intact molecule which is perfectly timed with the polymer degradation. While formulating these quercetin conjugated PβAE matrix into nanocarriers would allow for multiple delivery routes (oral, intravenous, inhalation etc.), well known oil-water nano

SUBMITTER: Gupta P 

PROVIDER: S-EPMC4609638 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature