Short-term forecasting of the prevalence of clinical trachoma: utility of including delayed recovery and tests for infection.

ABSTRACT:

Background

The World Health Organization aims to control blinding trachoma by 2020. Decisions on whether to start and stop mass treatments and when to declare that control has been achieved are currently based on clinical examination data generated in population-based surveys. Thresholds are based on the district-level prevalence of trachomatous inflammation-follicular (TF) in children aged 1-9 years. Forecasts of which districts may and may not meet TF control goals by the 2020 target date could affect resource allocation in the next few years.

Methods

We constructed a hidden Markov model fit to the prevalence of two clinical signs of trachoma and PCR data in 24 communities from the recent PRET-Niger trial. The prevalence of TF in children in each community at 36 months was

SUBMITTER: Liu F 

PROVIDER: S-EPMC4618840 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature