Ontology highlight
ABSTRACT:
SUBMITTER: Zhao N
PROVIDER: S-EPMC4621902 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Zhao Nan N Mao Yousheng Y Han Gaijing G Ju Qiang Q Zhou Lanping L Liu Fang F Xu Yang Y Zhao Xiaohang X
Oncotarget 20150701 21
Here we demonstrated that sepantronium bromide (YM155), a survivin suppressant, inhibited esophageal squamous-cell carcinoma (ESCC) growth in mice bearing human ESCC xenografts without affecting body weight. In cell culture, YM155 decreased survivin levels and caused PARP-1 activation, poly-ADP polymer formation, and AIF translocation from the cytosol to the nucleus. Genetic knockdown of PARP-1 or AIF abrogated YM155-induced parthanatos cell death. Furthermore, FOS, JUN and c-MYC gene transcript ...[more]