Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: Relevance for molecular diagnosis.

ABSTRACT:

Background

It is not clear whether cross-reactivity or cosensitization to glutathione S-transferases (GSTs) occurs in tropical and subtropical environments. In the United States, Bla g 5 is the most important GST allergen and lack of coexposure to GSTs from certain species allows a better assessment of cross-reactivity.

Objectives

To examine the molecular structure of GST allergens from cockroach (Bla g 5), dust mites (Der p 8 and Blo t 8), and helminth (Asc s 13) for potential cross-reactive sites, and to assess the IgE cross-reactivity of sensitized patients from a temperate climate for these allergens for molecular diagnostic purposes.

Methods

Four crystal structures were determined. Sera from patients allergic to cockroach and mite were tested for IgE reactivity t

SUBMITTER: Mueller GA 

PROVIDER: S-EPMC4624055 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature