Ontology highlight
ABSTRACT:
SUBMITTER: Segovia M
PROVIDER: S-EPMC4629416 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20140414 5
The administration of autologous (recipient-derived) tolerogenic dendritic cells (ATDCs) is under clinical evaluation. However, the molecular mechanisms by which these cells prolong graft survival in a donor-specific manner is unknown. Here, we tested mouse ATDCs for their therapeutic potential in a skin transplantation model. ATDC injection in combination with anti-CD3 treatment induced the accumulation of CD8(+) CD11c(+) T cells and significantly prolonged allograft survival. TMEM176B is an in ...[more]