Dataset Information

Long-term results of carmustine wafer implantation for newly diagnosed glioblastomas: a controlled propensity-matched analysis of a French multicenter cohort.

ABSTRACT:

Background

The standard of care for newly diagnosed glioblastoma is maximal safe surgical resection, followed by chemoradiation therapy. We assessed carmustine wafer implantation efficacy and safety when used in combination with standard care.

Methods

Included were adult patients with (n = 354, implantation group) and without (n = 433, standard group) carmustine wafer implantation during first surgical resection followed by chemoradiation standard protocol. Multivariate and case-matched analyses (controlled propensity-matched cohort, 262 pairs of patients) were conducted.

Results

The median progression-free survival was 12.0 months (95% CI: 10.7-12.6) in the implantation group and 10.0 months (9.0-10.0) in the standard group and the median overall survival was 20.4 months (19.0-22.7) and 18.0 months (17.0-19.0), respectively. Carmustine wafer implantation was independently associated with longer progression-free survival in patients with subtotal/total surgical resection in the whole series (adjusted hazard ratio [HR], 0.76 [95% CI: 0.63-0.92], P = .005) and after propensity matching (HR, 0.74 [95% CI: 0.60-0.92], P = .008), whereas no significant difference was found for overall survival (HR, 0.95 [0.80-1.13], P = .574; HR, 1.06 [0.87-1.29], P = .561, respectively). Surgical resection at progression whether alone or combined with carmustine wafer implantation was independently associated with longer overall survival in the whole series (HR, 0.58 [0.44-0.76], P < .0001; HR, 0.54 [0.41-0.70], P < .0001, respectively) and after propensity matching (HR, 0.56 [95% CI: 0.40-0.78], P < .0001; HR, 0.46 [95% CI: 0.33-0.64], P < .0001, respectively). The higher postoperative infection rate in the implantation group did not affect survival.

Conclusions

Carmustine wafer implantation during surgical resection followed by the standard chemoradiation protocol for newly diagnosed glioblastoma in adults resulted in a significant progression-free survival benefit.

SUBMITTER: Pallud J

PROVIDER: S-EPMC4633930 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Publications

Long-term results of carmustine wafer implantation for newly diagnosed glioblastomas: a controlled propensity-matched analysis of a French multicenter cohort.

Pallud Johan J Audureau Etienne E Noel Georges G Corns Robert R Lechapt-Zalcman Emmanuèle E Duntze Julien J Pavlov Vladislav V Guyotat Jacques J Hieu Phong Dam PD Le Reste Pierre-Jean PJ Faillot Thierry T Litre Claude-Fabien CF Desse Nicolas N Petit Antoine A Emery Evelyne E Voirin Jimmy J Peltier Johann J Caire François F Vignes Jean-Rodolphe JR Barat Jean-Luc JL Langlois Olivier O Dezamis Edouard E Parraga Eduardo E Zanello Marc M Nader Edmond E Lefranc Michel M Bauchet Luc L Devaux Bertrand B Menei Philippe P Metellus Philippe P

Neuro-oncology 20150716 12

<h4>Background</h4>The standard of care for newly diagnosed glioblastoma is maximal safe surgical resection, followed by chemoradiation therapy. We assessed carmustine wafer implantation efficacy and safety when used in combination with standard care.<h4>Methods</h4>Included were adult patients with (n = 354, implantation group) and without (n = 433, standard group) carmustine wafer implantation during first surgical resection followed by chemoradiation standard protocol. Multivariate and case-m ...[more]

PMID: 26185110

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Dataset Information

Long-term results of carmustine wafer implantation for newly diagnosed glioblastomas: a controlled propensity-matched analysis of a French multicenter cohort.

Background

Methods

Results

Conclusions

Publications

Long-term results of carmustine wafer implantation for newly diagnosed glioblastomas: a controlled propensity-matched analysis of a French multicenter cohort.

Similar Datasets

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